TREATMENT ACTIVITY AND NURSING VALUES OF A HETEROCYCLIC COMPOUND COMBINED WITH ASPIRIN ON TRAUMATIC ARTHRITIS
Abstract: Heterocyclic compound 2-(3-(ethoxycarbonyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid (1) designed using 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid (2, Febuxostat) as a starting material is successfully prepared via a multistage synthesis route and finally characterized by IR,1H NMR, and single crystal X-ray diffraction. Its treatment activity combined with aspirin on traumatic arthritis is evaluated along with the related mechanism. Firstly, the ELISA detection is conducted to determine the inflammatory response released into the joint cavity secretion. Additionally, real time RT-PCR is measured and the activation levels of NF-κb are determined after the indicated treatment. [Figure not available: see fulltext.]
Li, Y.,Wang, L.,Xu, J.,Yang, H.,Zhao, X.
p. 1563 - 1568
(2021/11/20)
HIGH-PURITY FEBUXOSTAT AND THE METHOD FOR PREPARATION
A febuxostat which purity is not less than 99.0%, method for preparation thereof, and pharmaceutical composition thereof. The method for preparation includes recrystallizing febuxostat in a mixed solvent. The said pharmaceutical composition can be used in
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Page/Page column 5
(2011/11/30)
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