- ETHYNYLBENZENE DERIVATIVES
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Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.
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Page/Page column 47
(2012/03/26)
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- [3R]-3-amino-1-hydroxy pyrrolidin-2-one and its use as a neuroprotective agent
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The present invention provides R(+)-3-amino-1-hydroxypyrrolidin-2-one of formula I: STR1 or pharmaceutically acceptable acid addition salt thereof, which compound is useful as an anticonvulsant agent and in the treatment and/or prevention of neurodegenerative disorders.
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- 4-N-Hydroxy-L-2,4-diaminobutyric acid. A strong inhibitor of glutamine synthetase
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Analogues of glutamic acid were synthesized and evaluated for their inhibitory activity toward glutamine synthetase (EC 6.3.1.2; GS). The title compound, 4-N-hydroxy-L-2,4-diaminobutyric acid (NH-DABA), showed a potent inhibitory activity against GS from
- Fushiya,Maeda,Funayama,Nozoe
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p. 480 - 483
(2007/10/02)
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