- Highly efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by heteropoly acids in water
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Heteropoly acids efficiently catalyzed the cyclocondensation reaction of anthranilamide with aldehydes in water at ambient temperature and afforded the corresponding 2,3-dihydro-4(1H)-quinazolinones compounds in good to excellent yields. This method provides mild reaction conditions and clean reaction profiles, using a small quantity of catalyst and a simple workup procedure.
- Zong, Ying Xiao,Zhao, Yan,Luo, Wen Cai,Yu, Xing Hai,Wang, Jun Ke,Pan, Yi
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- Poly(4-vinylpyridine) supported acidic ionic liquid: A novel solid catalyst for the efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones under ultrasonic irradiation
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A novel poly(4-vinylpyridine) supported acidic ionic liquid catalyst was synthesized by the reaction of 4-vinylpyridine with 1,3-propanesultone, followed by the polymerization and the addition of the heteropolyacid. Due to the combination of polymer features and ionic liquid, it acted as a heterogeneous catalyst to effectively catalyze the cyclocondensation reaction of anthranilamide with aldehydes under ultrasonic irradiation and afforded the corresponding 2,3-dihydro-4(1H)-quinazolinones compounds in good to excellent yields. In addition, the catalyst could be easily recovered by the filtration and reused six times without significant loss of catalytic activity. More importantly, the use of ultrasonic irradiation can obviously accelerate the reaction.
- Wang, Junke,Zong, Yingxiao,Fu, Rugang,Niu, Yuying,Yue, Guoren,Quan, Zhengjun,Wang, Xicun,Pan, Yi
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- A new concise synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives
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A new T3P-assisted, convenient and efficient procedure for the synthesis of dihydroquinazolinones is described. The main advantages of this protocol include its practical simplicity, short reaction times and particularly the ease with which products are isolated.
- Desroses, Matthieu,Scobie, Martin,Helleday, Thomas
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supporting information
p. 3595 - 3597
(2013/11/06)
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