Perylenyltriazoles inhibit reproduction of enveloped viruses
1-Substituted 4-perylen-2(3)-yl-1,2,3-triazoles, easily accessible by ‘click’ reaction and combining in one molecule a polyaromatic unit and a nitrogen heterocycle, were found to strongly inhibit the reproduction of enveloped viruses. 5-[4-(Perylen-3-yl)-
Aralov, Andrey V.,Proskurin, Gleb V.,Orlov, Alexey A.,Kozlovskaya, Liubov I.,Chistov, Alexey A.,Kutyakov, Sergey V.,Karganova, Galina G.,Palyulin, Vladimir A.,Osolodkin, Dmitry I.,Korshun, Vladimir A.
Highly efficient and facile synthesis of 5-azido-2'-deoxyuridine
Previously reported syntheses of the photoaffinity label 5-azido-2'-deoxyuridine are rather inefficient and involve the tedious preparation of a 5-nitro intermediate. To overcome these inconveniences, we have developed a new approach from the commercially available 5-bromo-2'- deoxyuridine nucleoside. Our synthetic route makes use of a benzylamination reduction sequence. Using this strategy, the 5-azido-2'-deoxyuridine photolabel is prepared in three steps and quantitative yields. Copyright Taylor and Francis Group, LLC.