- Pd-Catalyzed direct C-H arylation of pyrrolo[1,2-a] quinoxalines
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An efficient Pd-catalyzed direct C-H arylation of pyrrolo[1,2-a]quinoxalines with aryl iodides is described, providing a selective route toward a series of 1-arylated and 1,3-diarylated pyrrolo[1,2-a]quinoxalines in good yields. This method features a broad substrate scope, good functional group tolerance and gram-scale synthesis. Furthermore, the C3-thiocyanation of the arylated product is also achieved. We believe that these novel aryl-substituted pyrrolo [1,2-a]quinoxalines will have a variety of applications in organic synthesis and medicinal chemistry.
- Gu, Yanlong,Hao, Di,Li, Chuntian,Li, Yang,Liu, Jichang,Liu, Ping,Liu, Yali,Vaccaro, Luigi,Yang, Zhen
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supporting information
p. 847 - 851
(2022/02/03)
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- An efficient synthesis of 1,3-diaryl-pyrrolo[1,2-a]quinoxalines from 2-(1h-pyrrol-1-yl)phenylamines
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The condensation of 1,3-diaryl-4-bromo-2-buten-1-ones with o-phenylenediamine leads to 2-[2,4-diaryl-1H-pyrrol-1-yl]phenylamines. Heating solutions of these compounds in formic acid leads to formylation and intramolecular condensation to give 1,3-diarylpy
- Potikha,Kovtunenko
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experimental part
p. 1396 - 1400
(2010/06/12)
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