- CAL-B-mediated efficient synthesis of a set of valuable amides by direct amidation of phenoxy- and aryl-propionic acids
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An efficient, easy and sustainable amidation of a set of non-activated carboxylic acids with anilines, assisted by CAL-B, as biodegradable catalyst, is reported. The enzymatic amidation reactions are performed on set of nonsteroidal anti-inflammatory drugs (NSAIDs), phenoxypropionic acid and protected-prolines by direct condensation of one equivalent of carboxylic acids and two equivalents of anilines derivatives in heptane after 72?h of reaction at 80?°C. The obtained carboxylic amides are recovered with isolated chemical yields varied between moderate and excellent. Fourteen from them are reported for the first time, and an X-ray crystal is obtained for: N-(4-iodophenyl)-2-(4-isobutylphenyl)propanamide 1d.
- Benamara, Nourelhouda,Merabet-Khelassi, Mounia,Aribi-Zouioueche, Louisa,Riant, Olivier
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p. 4045 - 4053
(2021/04/21)
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- Direct amination of phenols under metal-free conditions
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Herein, we disclose the metal-free synthesis of arylamines via the direct amination of phenols using aminating reagents. This reaction procedure uses easy accessible aminating reagents and provides a versatile synthetic route to a broad range of arylamines with various functionalities in good to excellent yield. By using a two-step route of amination and oxidative coupling reaction, we synthesized three naturally occurring carbazole alkaloids: murrayafoline A, mukonine, and clausenine from two commercially available phenols. Georg Thieme Verlag Stuttgart · New York.
- Yu, Jianzhong,Wang, Yongtao,Zhang, Peizhi,Wu, Jun
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supporting information
p. 1448 - 1454
(2013/07/26)
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- A simple enantioconvergent and chemoenzymatic synthesis of optically active α-substituted amides
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Simple and efficient: The combination of an enzymatic, enantioinverting reaction with simple follow-up processes allows the transformation of readily available racemic compounds into versatile chiral α-substituted amides (see picture; Ms=methanesulfonyl).
- Szymanski, Wiktor,Westerbeek, Alja,Janssen, Dick B.,Feringa, Ben L.
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p. 10712 - 10715
(2011/12/05)
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- Phenoxypropiothioamides as additives to oils
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Continuing research in the field of synthesizing effective additives among thioamide derivatives, new compounds -phenoxypropiothioamides - have been synthesized and investigated as additives to lubricant M-11.
- Kuliyev,Akhadov,Aliyev,Rustamov
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p. 441 - 445
(2007/10/02)
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