- Acyl urea compound containing 1,3-dimethyl-1H-pyrazole structure and preparation method and application thereof
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The invention discloses an acyl urea compound containing a 1,3-dimethyl-1H-pyrazole structure and a preparation method and application thereof. The preparation method comprises the following steps: firstly using ethyl acetoacetate, triethyl orthoformate and methylhydrazine as raw materials to synthesize 1,3-dimethyl-1H-pyrazole-4-formic acid, performing the amidation to obtain 1,3-dimethyl-1H-pyrazole-4-formamide, and reacting with oxalyl chloride and substituted anilines to obtain a final product (I). The raw materials are simple and are easily obtained, the preparation method is simple, the aftertreatment is convenient, and the product yield is high. The compound has the antifungal activity, and has the good sterilizing effect in allusion to sclerotinia sclerotiorum, rhizoctonia solani, Cercospora arachidicola Hori, Macrophoma kawatsukai, and alternaria solani especially. The foundation is provided for new pesticide research and development.
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Paragraph 0029
(2017/09/05)
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- CYCLIZATION OF VICINAL ACETYLENIC DERIVATIVES OF PYRAZOLECARBONAMIDES AND BENZAMIDES
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Vicinal acetylenic derivatives of pyrazolecarbonamides and benzamides cyclize in alcoholic solution in the presence of KOH with closure of the six- or five-membered lactam ring.The formation of γ-lactam (from o-phenylethynylbenzamide) has been noted for t
- Vasilevskii, S. F.,Shvartsberg, M. S.
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p. 1901 - 1905
(2007/10/02)
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