Total synthesis of (+)-korupensamine B via an atropselective intermolecular biaryl coupling
The asymmetric total synthesis of nonracemic korupensamine B is reported. It includes a newly designed and highly trans-diastereoselective (>20:1 dr) route to the tetrahydroisoquinoline ring and an unprecedented atropdiastereoselective Suzuki-Miyaura coupling for construction of the fully fashioned naphthylisoquinoline framework that invokes π stacking as a possible source of stereocontrol.
Huang, Shenlin,Petersen, Tue B.,Lipshutz, Bruce H.
supporting information; experimental part
p. 14021 - 14023
(2011/01/04)
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