- Preparation of diverse BODIPY diesters
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The synthesis and properties of a variety of substituted BODIPY diesters is presented. We find that certain substitution patterns afford appreciable yields of the target compounds and that electronic effects result in predicable differential fluorescent behavior. Challenges to further water solubilize these dyes and/or provide new points of attachment for biological tagging remain, these strategies are discussed.
- Abeywardana, Sewwandi,Cantu, Annabelle L.,Nedic, Teodora,Schramm, Michael P.
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p. 3393 - 3396
(2018/08/17)
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- INHIBITORS OF METALLO-BETA-LACTAMASES
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The present invention relates to compounds of Formula (I) that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection. (Formula (I))
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Paragraph 00239; 00240
(2018/12/13)
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- Modular preparation of diverse dipyrrolemethanes
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A modular synthesis of polyfunctional dipyrrolemethanes is presented. Diverse side chains are introduced to 2-carboxypyrrole building blocks in two to four steps, resulting in a collection of substituted pyrroles that, when condensed in one step, give ris
- Pham, Cindy C.,Park, Michelle H.,Pham, Jenny Y.,Martin, Sadie G.,Schramm, Michael P.
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p. 1165 - 1173
(2013/06/05)
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- NOVEL FUSED PYRIDAZINE DERIVATIVES
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The present invention relates to novel fused pyridazine compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.
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- 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments
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1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides corresponding to formula I methods for their production, pharmaceutical compositions containing them, and the use thereof for noradrenalin receptor regulation, particularly for inhibiting noradrenalin reuptake, and/or for 5-HT receptor regulation, particularly for inhibiting 5-hydroxy tryptophan reuptake, and/or for opioid receptor regulation and/or for batrachotoxin (BTX) receptor regulation and/or for treating or inhibiting pain and other conditions.
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Page/Page column 32
(2009/06/27)
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- PYRROLE ANTIFUNGAL AGENTS
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The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
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Page/Page column 82-83
(2009/12/05)
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- Synthesis of new polydentate tweezers ligands of amido-amine type
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A series of new tweezers amido-amine ligands containing pyrrole, bipyrrole, and dipyrrolylmethane fragments were synthesized by reaction of 2-thioxothiazolidin-3-yl derivatives of α-pyrrolecarboxylic acids {5-[1-(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl
- Boev,Ustynyuk
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p. 297 - 304
(2007/10/03)
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- Synthesis of Phenylpyrrolylpyrroles. Part III
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Several ethyl 3-[(3-aryl-4-methyl)-2(1H)-pyrrolyl]-4-methyl-1H-pyrrole-2-carboxylates have been synthesized using two successive ethyl isocyanide addition-cyclizations to the appropriate nitropropene derivatives.
- Dumoulin,Rault,Robba
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- Phenylpyrrolic compounds used as drugs, their preparation and application
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The present invention relates to phenylpyrrole compounds, pharmaceutical compositions, preparation and to their application as an active principle, especially as a drug having antimitotic activity.
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