A number of new Schiff's bases of gossypol with aromatic amines and sulfanilamide compounds has been obtained.It has been shown by UV and PMR spectroscopy and x-ray structural analysis that in some solvents they exist predominantly in the quinoid form.For dianilinegossypol (in the solid state) the quinoid structure has been demonstrated and two polymorphic modifications have been revealed by x-ray structural analysis.
Baram, N. I.,Kamaev, F. G.,Ziyaev, Kh. L.,Biktimirov, L.,Ismailov, A. I.,et al.
Design, synthesis, and biological activities of aromatic gossypol schiff base derivatives
A series of aromatic gossypol Schiff bases have been successfully synthesized via a feasible chemical modification. The antiviral activity against tobacco mosaic virus (TMV) of these gossypol Schiff bases has been tested for the first time. The bioassay studies indicated most of these derivatives exhibited excellent anti-TMV activity, in which o-trifluoromethylaniline Schiff base (19) displayed the best antiviral activities. Furthermore, compound 19 exhibited an eminent anti-TMV effect in the field and low toxicity to mice. These results suggest it is a promising candidate for the inhibitor of plant virus.
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