- Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones
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8-Nitro-1,3-benzothiazin-4-ones (BTZs), with BTZ043 and PBTZ169 as the most advanced compounds, represent a new class of potent antitubercular agents, which irreversibly inhibit decaprenylphosphoryl-β-d-ribose-2′-epimerase (DprE1), an enzyme crucial for c
- Madikizela, Balungile,Eckhardt, Tamira,Goddard, Richard,Richter, Adrian,Lins, Anika,Lehmann, Christoph,Imming, Peter,Seidel, Rüdiger W.
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p. 1523 - 1533
(2021/06/14)
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- The flocculated acryloyldimethyltauric molecule ligand
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Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.
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Paragraph 0753
(2016/10/08)
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- 6-bromo-8-(4-[3H]methoxybenzamido)-4-oxo-4H-chromene-2- carboxylic acid: A powerful tool for studying orphan G protein-coupled receptor GPR35
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The potent and selective GPR35 agonist 6-bromo-8-(4-methoxybenzamido)-4- oxo-4H-chromene-2-carboxylic acid (12) was obtained in tritium-labeled form, designated [3H]PSB-13253, with a specific activity of 36 Ci (1.33 TBq)/mmol. Radiolabeling was
- Thimm, Dominik,Funke, Mario,Meyer, Anne,Müller, Christa E.
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p. 7084 - 7099
(2013/10/01)
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- FUNGICIDAL PYRAZOLONES
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Compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, Formula (1): wherein R1, R2, Q1, Q2 and Y are as defined in the disclosure. Also disclosed are compositions containing the comp
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Page/Page column 36
(2011/05/11)
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- A convenient synthesis of 4-alkoxy- and 4-hydroxy-2,6-difluoroanilines
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Two independent synthetic pathways for the preparation of 4-methoxy, 4-benzyloxy and 4-hydroxy-2,6-difluoroanilines, versatile building blocks in medicinal chemistry, based on diazonium coupling or Curtius-type rearrangements are presented.
- Alonso-Alija, Cristina,Michels, Martin,Peilst?cker, Karen,Schirok, Hartmut
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- The Synthesis and Transition Temperatures of Some Fluoro-Substituted 4-Cyanophenyl and 4-Cyanobiphenyl-4'-yl 4-Pentyl- and 4-Butoxy-Benzoates
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A series of 4-cyanophenyl 4-X-benzoates and a series of 4-cyanobiphenyl-4'-yl 4-X-benzoates (X= pentyl, butoxy) have been prepared without fluoro-substitution and with mono-fluoro to tetra-fluoro-substitution; all possible combinations of substitution patterns at the positions ortho- to the cyano group and ortho- to the carboxylate group have been obtained in an attempt to determine the structural features which are responsible for some members of these series showing very large positive values of dielectric anisotropy.The synthesis of novel precursors required for the preparation of these esters is described and the melting points and transition temperatures of the esters are discussed and an explanation is provided for the variation of Tn-1 values with position and extent of fluoro-substitution. - Keywords: Fluoro-substitution, phenyl and biphenyl benzoates, terminal cyano namatogens.
- Gray, G. W.,Hird, M.,Lacey, D.,Toyne, K. J.
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p. 165 - 190
(2007/10/02)
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