- An efficient synthesis of 13C12-benzoyl peroxide
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13C12-Benzoyl peroxide was prepared in overall yield of 78% from 13C6-benzene via acetophenone, benzoic acid and benzoyl chloride intermediates.
- Breuer, Stephen W.
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- Preparation of remacemide hydrochloride labelled with carbon-14, carbon-13, deuterium and tritium
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The anti-epileptic agent remacemide hydrochloride has been prepared labelled with 14C, from [carbonyl-14C]acetophenone, and with 13C from [13C6]benzene, [1,2-13C]acetyl chloride and [1-13C]glycine. [2-3H]Glycine was utilised to prepare remacemide labelled with tritium at low specific activity. In addition other 2H- and high specific activity 3H-isotopomers of the drug, and of an active metabolite of the drug, were prepared by hydrogen isotope exchange methodology. The R-12C/S-14C and S-12C/R-14C pseudoracemic drugs were also prepared by a synthesis involving resolution of a 14C-labelled amine intermediate via fractional crystallisation of the dibenzoyltartrate salts.
- Coombs,Dawson,Fedorchuk,Kingston,Lockley,Mather,McLachlan,Morlin,Spink,Wilkinson
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p. 533 - 543
(2007/10/03)
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- Synthesis of 14C-labeled levamisole and 13C-labeled tetramisole
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The syntheses of 14C-ring labeled levamisole ([-]-2,3.5,6-tetrahydro-6-phenyl[14C-UL)imidazo[2,1- b]thiazole) from acetophenone-ring-UL-14C in 5 steps plus resolution with a 7.5% overall yield, and 13C6/su
- Feil
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p. 1071 - 1076
(2007/10/03)
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