One-pot synthesis of novel 2-(benzofuran-2-yl)-4-phenylquinoline-3-carboxylates
A facile and efficient synthesis of novel ethyl 2-(benzofuran-2-yl)-4-phenylquinoline-3-carboxylates and the corresponding acids through the one-pot three-step reaction of ethyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate with a series of salicylalde
Friedlaender synthesis of quinolines using a lewis acid-surfactant- combined catalyst in water
In water, Friedlaender annulation using Lewis acid-surfactant-combined catalyst provides a mild and efficient route for the synthesis of quinolines. Employing a catalytic amount of scandium tris(dodecyl sulfate) [Sc(O 3SOC12H2/
Synthesis and antibacterial activity of substituted quinoline derivatives
An efficient and convenient method is reported for the synthesis of various substituted quinolines through the condensation of o-amino aryl carbonyls with ketones containing an active methylene group in the presence of CuSO4·5H2O as
Ravindra,Rani, Alka
p. 1891 - 1894
(2016/07/06)
Structure-activity relationships of novel iodinated quinoline-2- carboxamides for targeting the translocator protein
In an effort to develop a new SPECT imaging agent for the translocator protein (TSPO), a series of novel iodinated quinoline-2-carboxamides have been synthesised and evaluated for binding affinity using rat brain homogenates. The outcome of the biological testing in combination with HPLC determination of the physicochemical properties of these compounds directed the design of new analogues resulting in 4-(2-iodophenyl)quinoline-2-N-diethylcarboxamide, a new TSPO ligand with higher affinity than the widely used clinical imaging agent PK11195.
Blair, Adele,Stevenson, Louise,Dewar, Deborah,Pimlott, Sally L.,Sutherland, Andrew
supporting information
p. 1461 - 1466
(2013/11/19)
An efficient access to the synthesis of novel 12-phenylbenzo[6,7]oxepino[3, 4-b]quinolin- 13(6H)-one derivatives
An efficient access to the tetracyclic-fused quinoline systems, 12-phenylbenzo[6,7]oxepino[3,4-b]quinolin-13(6H)-one derivatives 4a-l, is described, involving the intramolecular Friedel-Crafts acylation reaction of 2-(phenoxymethyl)-4-phenylquinoline-3- c
New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein
With the aim of developing new SPECT imaging agents for the translocator protein (TSPO), a small library of iodinated quinoline-2-carboxamides have been prepared and tested for binding affinity with TSPO. N,N-Diethyl-3-iodomethyl-4-phenylquinoline-2-carboxamide was found to have excellent affinity (Ki 12.0 nM), comparable to that of the widely used TSPO imaging agent PK11195.
Chlorotrimethylsilane-mediated friedlaender synthesis of polysubstituted quinolines
New convenient conditions for the Friedlander synthesis of quinolines are described. Polysubstituted quinolines were readily prepared using chlorotrimethylsilane as a promoter and water-acceptor agent. Georg Thieme Verlag Stuttgart.
Ryabukhin, Sergey V.,Volochnyuk, Dmitriy M.,Plaskon, Andrey S.,Naumchik, Vasiliy S.,Tolmachev, Andrei A.
p. 1214 - 1224
(2008/02/02)
Synthesis and 5HT-receptors affinity of some 4-phenylquinoline derivatives
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Anzini,Vomero,Garofalo,Cappelli,Cagnotto
p. 555 - 563
(2007/10/02)
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