Synthesis, pharmacological activity and structure affinity relationships of spirocyclic σ1 receptor ligands with a (2-fluoroethyl) residue in 3-position
In order to develop a fluorinated radiotracer for imaging of σ1 receptors in the central nervous system a series of (2-fluoroethyl) substituted spirocyclic piperidines 3 has been prepared. In the key step of the synthesis 2-bromocinnamaldehyde
Maestrup, Eva Gro?e,Wiese, Christian,Schepmann, Dirk,Brust, Peter,Wünsch, Bernhard
scheme or table
p. 393 - 405
(2011/02/27)
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