- Total synthesis, absolute configuration, and biological activity of xyloallenoide A
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The novel natural product xyloallenoide A, isolated from the marine mangrove endophytic fungus from the South China Sea, and its diastereoisomer xyloallenoide A1, which contain N-methyl-substituted amino acids, were synthesized. The absolute configurations of the amino acid units of xyloallenoide A were finally confirmed to be L-Lys, Me-D-Val, and Me-L-Ala. This report represents a practical and attractive alternative for the synthesis of N-methyl-substituted cyclotripeptides. In the preliminary bioassay, synthetic xyloallenoide A showed marginal activities against KB (IC50=9.6 mm) and KBv200 cells (IC50=10.3 μm), and xyloallenoide A1 was inactive against KB and KBv200 cells.
- Wang, San-Yong,Xu, Zhong-Liang,Wang, Hui,Li, Chun-Rong,Fu, Li-Wu,Pang, Ji-Yan,Li, Jing,She, Zhi-Gang,Lin, Yong-Cheng
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p. 973 - 982
(2012/08/08)
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- Marine cyclotripeptide X-13 promotes angiogenesis in zebrafish and human endothelial cells via PI3K/Akt/eNOS signaling pathways
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Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or L-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways.
- Lu, Xi-Lin,Xu, Zhong-Liang,Yao, Xiao-Li,Su, Feng-Juan,Ye, Cheng-Hui,Li, Jing,Lin, Yong-Cheng,Wang, Guang-Lei,Zeng, Jin-Sheng,Huang, Ru-Xun,Ou, Jing-Song,Sun, Hong-Shuo,Wang, Li-Ping,Pang, Ji-Yan,Pei, Zhong
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p. 1307 - 1320
(2012/08/08)
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