- Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)
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A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR2R3 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via π-π interaction. Introduction of substituting group on the N4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 μM/kg, sc) and holds promise for development as a mechanically new analgesic drug.
- Lin, Song-Wen,Sun, Qi,Ge, Ze-Mei,Wang, Xin,Ye, Jia,Li, Run-Tao
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p. 940 - 943
(2011/03/21)
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- Selective ratiometric detection of Hg2+ in pure water using a phenoxazinium-based probe
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A ratiometric, near-infrared, and fully water-soluble probe, a phenoxazinium-based chemosensor bearing an anilino thiaazacrown, was successfully synthesized and characterized. The use of this probe for the selective ratiometric detection of Hg2+/sup
- Yang, Xue-Bo,Ge, Jian-Feng,Xu, Qing-Feng,Zhu, Xiao-Ling,Li, Na-Jun,Gu, Hong-Wei,Lu, Jian-Mei
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supporting information; experimental part
p. 2492 - 2495
(2011/05/09)
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