- Lewis acid mediated reactions of zirconacyclopentadienes with aldehydes: One-pot synthetic route to indene and cyclopentadiene derivatives from aldehydes and benzyne or alkynes
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One-pot procedures for the preparation of highly substituted indenes, tetrahydroindenes, and cyclopentadienes have been developed by using a combination of zirconocene-mediated C-C-bond-forming reactions with Lewis acid mediated activation of carbonyl groups. The carbonyl groups of aldehydes were deoxygenated in the reaction and behaved formally as a one-carbon unit. A variety of Lewis acids were checked and showed different reactivities in this reaction.
- Zhao, Changjia,Li, Pixu,Cao, Xiaoyu,Xi, Zhenfeng
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- Deoxygenative cycloaddition of aldehydes with alkynes mediated by AlCl3 and zirconium: Formation of cyclopentadiene derivatives
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Cleavage of the aldehyde C=O bond takes place in the zirconocene- and AlCl3-mediated cyclization of two molecules of an alkyne with an aldehyde to afford cyclopentadiene derivatives [Eq. (1)]. Only one of the possible double-bonds isomers is fo
- Xi, Zhenfeng,Li, Pixu
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- NOVEL IRIDIUM/RHODIUM ANTI-CANCER COMPOUNDS
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The present invention relates to novel iridium and/or rhodium containing complexes for use as a cytotoxic, such as an anti-cancer agent. There is also provided a method of preparing said compounds.
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Page/Page column 37-38
(2011/12/14)
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- Preparation and characterization of (C5Me4Ph)TiCl3, the oxochloride complexes [(C5Me4Ph)TiCl2]2( μ-O) and [(C5Me4Ph)TiCl( μ-O)]3 and the oxo-complex [(C5Me4Ph)Ti]4( μ-O)6
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The titanium compound (C5Me4Ph)TiCl3 (1) can be prepared by the reaction of (C5Me4Ph)SiMe3 with TiCl4. Hydrolysis of 1 in the presence of HNEt2 or Ag2O has allowed for the isolation of the oxochloride complexes [(C5Me4Ph)TiCl2]2( μ-O) (2) and [(C5Me4Ph)TiCl( μ-O)]3 (3), respectively. The NMR spectra of 3 are consistent with a nearly flat Ti3O3 ring having down-up-up or E-Z-Z arrangement of (C5Me4Ph)-ligands around the ring. The X-ray crystal structure of 2 (monoclinic, space group C2/c, a = 19.847(12), b = 9.089(5), c = 20.405(13) A, β = 124.06(5)°) consists of trans [(C5Me4Ph)TiCl2]2( μ-O) molecules of C2 symmetry with nearly linear Ti-O-Ti units (169.3(2)°). Reaction of 1 with an excess of H2O/HNEt2 results in the formation of the oxo-complex [(C5Me4Ph)Ti]4( μ-O)6 (4). The X-ray crystal structure of 4 (triclinic, space group P1, a = 11.861(5), b = 12.706(5), c = 18.218(8) A, α = 87.58(3)°, β = 89.00(3)°, γ = 86.60(3)°) reveals that the molecules of 4 have an adamantane-like Ti4O6 cage of nearly Td symmetry. The NMR spectra and molecular structures of 1, 2, 3 and 4 are discussed.
- Bjoergvinsson, Mar,Halldorsson, Snorri,Arnason, Ingvar,Magull, Joerg,Fenske, Dieter
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p. 207 - 215
(2007/10/03)
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