- Preparation method of dacomitinib intermediate
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The invention provides a preparation method of a dacomitinib intermediate. The preparation method comprises steps shown in the specification. The invention provides the novel preparation method of the dacomitinib key intermediate, the intermediate is short in synthetic route, mild in reaction condition, short in reaction time and simple in separation and purification method, raw materials and reagents are conventional reagents, the cost is low, the yield of the prepared product is high, and the method is very beneficial to industrial production and popularization and has a good application prospect.
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- Preparation method of Dactinib key intermediate
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The invention provides a preparation method of a Dacomitinib key intermediate. The preparation method comprises the following steps: taking Dacomitinib as a raw material; the intermediate is short in synthetic route, mild in reaction condition, short in reaction time, simple in separation and purification method and low in cost, raw materials and reagents are all conventional reagents, and the prepared product is high in yield and quite beneficial to industrial production and popularization and has good application prospects.
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