Synthesis of 4-(ω-aminoalkyl)- or 4-(ω-lactamiminoalkyl)thiazoles by ring chain transformation of isothioureas with lactam derivatives
CH-Acidic isothioureas 1 react with lactam acetals 2 at the unsubstituted N-atom as well as at the acidic S-methylene group giving 4-(ω-aminoalkyl)thiazoles 6. The latter are further transformed to 4-(ω-lactamiminoalkyl)thiazoles 8, if lactim ethers 3 are used in reactions with isothioureas 1.
Radics,Liebscher,Patzel
p. 673 - 677
(2007/10/02)
Ring transformation via bridged 1,3-dicarbonyl heteroanalogs; part II. Synthesis of 4-(ω-aminoalkyl)-thiazoles by a novel ring transformation reaction of semicyclic thioacylamidines with acidic methyl halides
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Liebscher,Patzel,Bechstein
p. 968 - 970
(2007/10/02)
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