- Use of GABA and GABAB agonists
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The present invention provides methods of stimulating tissue growth, including islet cell growth, by administering GABA or a GABA agonist to act on GABAB receptors and GABAB-like receptors to activate cell replication.
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- Use of GABAB receptor agonists as reflux inhibitors
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PCT No. PCT/SE97/01555 Sec. 371 Date Nov. 12, 1997 Sec. 102(e) Date Nov. 12, 1997 PCT Filed Sep. 15, 1997 PCT Pub. No. WO98/11885 PCT Pub. Date Mar. 26, 1998The present invention relates to the use of GABAB receptor agonists for the inhibition of transient lower esophageal sphincter relaxations, and for the treatment of gastro-esophageal reflux disease.
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- Substituted aminoalkylphosphinic acids
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P-substituted aminoalkylphosphinic acids of the formula STR1 wherein R denotes an optionally fluorinated methyl group, R1 denotes hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or a fluorinated methyl group and R2 and R3 denote hydrogen or R2 denotes hydroxy, lower alkoxy or halogen and R3 is hydrogen or R2 and R3 together represent an oxo group, and their pharmaceutically acceptable salts are active as GABAB- agonists and can be used in the treatment of spinal spasticity, multiple sclerosis and cerebral palsy, trigeminus neuralgia, drug withdrawal syndromes and/or conditions of pain. They can be manufactured by methods known per se and suitable such methods are described.
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