- 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT(1B)) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole
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The synthesis and in vitro and in vivo characteristics of 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one (1, CP-93,129) are described. This rotationally restricted phenolic analogue of RU-24,969 is a potent (15 nM) and selective (200x vs the 5-
- Macor,Burkhart,Heym,Ives,Lebel,Newman,Nielsen,Ryan,Schulz,Torgersen,Koe
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p. 2087 - 2093
(2007/10/02)
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- THE SYNTHESIS OF ROTATIONALY RESTRICTED PHENOLIC ANALOG OF 5-METHOXY-3-(1,2,5,6-TETRAHYDROPYRID-4-YL)INDOLE (RU-24,969)
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Pyrrolopyrid-5-one represents a rotationally restricted phenolic analog of 5-hydroxyindole.The synthesis of the rotationally restricted phenolic analog of the serotonin agonist, 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole (RU-24,969), is prese
- Macor, John E.,Newman, Michael E.
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p. 805 - 809
(2007/10/02)
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