- One-Pot Access towards 4,5-Disubstituted 2-Amino-1H-imidazoles Starting from Mannich Substrates and their Transformation Utilities
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An efficient protocol for the preparation of 4,5-functionalised 2-amino-1H-imidazoles as fragment-like structures was developed in isolated yields up to 95 %. The demonstrated one-pot manner includes an intramolecular oxidative annulation and ring cleavage sequence starting from Mannich precursors. The suggested one-pot sequential synthetic methodology is easy to apply in automatic and robotic chemistry laboratories for which a rapidly increasing demand is foreseen because of the ongoing revolution in the field of continuous manufacturing of pharmaceutical drug substances and products. Further transformation utilities such as Groebke–Blackburn–Bienaymé 3CR and the formation of marine alkaloid analogs were also represented.
- Bényei, Attila,Kanizsai, Iván,Makra, Zsófia,Puskás, László G.
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p. 7184 - 7196
(2020/12/01)
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- CBr4 Mediated Oxidative C-N Bond Formation: Applied in the Synthesis of Imidazo[1,2-α]pyridines and Imidazo[1,2-α]pyrimidines
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The carbon tetrabromide mediated oxidative carbon-nitrogen bond formation of 2-aminopyridines or 2-aminopyrimidines with β-keto esters or 1,3-diones, leading to a variety of complex imidazo[1,2-α]pyridines or imidazo[1,2-α]pyrimidines, is reported. The re
- Huo, Congde,Tang, Jing,Xie, Haisheng,Wang, Yajun,Dong, Jie
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supporting information
p. 1016 - 1019
(2016/03/15)
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- Reactions of (Vinylimino)phosphoranes and Related Compounds: Access to the Azacarbolines and -aplysinopsines
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Aza-Wittig-type reactions of iminophosphoranes 3a, 14a,b and 19, derived from azidovinyl (or -phenyl) derivatives and triphenylphosphine, with methyl or phenyl isocyanates were used to construct the framework of the azacarboline structures 7a,b-10, 20, 21
- Chavignon, Olivier,Teulade, Jean C.,Roche, Danielle,Madesclaire, Michel,Blache, Yves,et al.
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p. 6413 - 6418
(2007/10/02)
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