Streamlined synthesis of (R, R)-rhizoferrin, (S, S)-rhizoferrin and (R, S, R)-staphyloferrin A
(R, R)-Rhizoferrin and (R, S, R)-staphyloferrin A are carboxylate-type siderophores. Their streamlined synthesis has been accomplished starting from (R)-citric acid. Key-step of these syntheses is a chemo-enzymatic ester hydrolysis. (S, S)-rhizoferrin was accessible by a multistep synthesis starting from an (S)-citrate derived synthon.
Csuk, René,Deising, Holger B.,Raschke, Anja,Serbian, Immo,Wiese, Jana
Chemical synthesis of staphyloferrin A and its application for Staphylococcus aureus detection
The chemical synthesis of staphyloferrin A, a siderophore used by Staphylococcus bacteria for ferric iron retrieval, has been achieved with 79% yield via solid phase peptide synthesis (SPPS). Biological activity of synthetic staphyloferrin A has been confirmed by demonstrating its capture and uptake by live S. aureus.
Pandey, Rajesh K.,Jarvis, Gregory G.,Low, Philip S.
p. 1707 - 1710
(2014/03/21)
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