Improved Synthesis of N1-Pyridylthiamine Pyrophosphate, a Coenzymatically Active Analog of Thiamine Pyrophosphate
Our previously published synthesis of the N1-pyridyl analog 1b of thiamine pyrophosphate is improved resulting in a remarkably higher yield.Key reaction of this new synthetic pathway is the oxidative degradation of 5-acetylpyridine 8 to the 5-carboxylic acid 11 via the pyridinium compound 10.Improved preparations of other intermediates are also described.The N1-pyridylthiamine pyrophosphate analog 1b has been separated and purified by ion exchange chromatography on Sephadex A-25.
Neef, Holger,Golbik, Ralph,Fahlbusch, Baerbel,Schellenberger, Alfred
p. 913 - 916
(2007/10/02)
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