Amino Acid Synthesis Using (L)-Pyroglutamic Acid as a Chiral Starting Material
Deprotonation of protected pyroglutamates 1(c), 1(d), and 1(e) with lithium di-isopropylamine (LDA) or lithium hexamethyldisilazide (LiHDMS) in THF, followed by reaction with electrophiles, leads to the formation of 4-substituted pyroglutamates in good yield.This approach has been used for the synthesis of the novel amino acid (4).Key Words: pyroglutamic acid; chiral amino acid synthesis
Baldwin, Jack E.,Miranda, Tania,Moloney, Mark,Hokelek, Tuncer