The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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Page/Page column 106
(2020/04/25)
Stereoselective conversion of tetraalkyltin compounds to alcohols
A stereoselective method for the conversion of a tributyltin group at an unactivated carbon atom has been achieved. Reaction with bromine leads to preferential cleavage of a butyl group, giving an alkylbromodibutylstannane. Subsequent reaction with basic peroxide leads to preferential cleavage of the more-substituted carbon-tin bond and formation of the corresponding alcohol with retention of configuration.
Herndon,Wu
p. 6461 - 6464
(2007/10/02)
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