- Two succinic acid derivatives of 2-ethyl-6-methyl-pyridin-3-ol
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Crystals of bis(2-ethyl-3-hy-droxy-6-methyl-pyridinium) succin-ate-succin-ic acid (1/1), C8H12NO+·0.5C4H4O4 2-·0.5C4H6O4, (I), and 2-ethyl-3-hy-droxy-6-methyl-pyridinium hydrogen suc-cinate, C8H12NO+·C4H5O4 -, (II), were obtained by reaction of 2-ethyl-6-methyl-pyridin-3-ol with succinic acid. The succinate anion and succinic acid mol-ecule in (I) are located about centres of inversion. Inter-molecular O - H...O, N - H...O and C - H...O hydrogen bonds are responsible for the formation of a three-dimensional network in the crystal structure of (I) and a two-dimensional network in the crystal structure of (II). Both structures are additionally stabilized by π-π inter-actions between symmetry-related pyridine rings, forming a rod-like cationic arrangement for (I) and cationic dimers for (II).
- Lyakhov, Alexander S.,Ivashkevich, Ludmila S.,Survilo, Vladimir L.,Trukhachova, Tatjana V.
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- ALKYL SUBSTITUTED 3-HYDROXYPYRIDINES FOR THE TREATMENT OF DEPRESSION
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The present invention relates to the use of compounds of formula (I) wherein R1 is selected from the group consisting of C1-8alkyl; R2 is selected from the group consisting of C1-8alkyl; R3 is selected from the group consisting of H and C1-8alkyl; and R4 is selected from the group consisting of C1-8alkyl; or a pharmaceutically acceptable salt thereof for the treatment of depression, preferably anxious depression.
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Paragraph 0030
(2014/02/15)
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