- SPIROUREA DERIVATIVES
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The invention relates to compounds of Formula (I) wherein X1, X2, X3, Y, R1, R2A, R2B, R3, and R4 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.
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Page/Page column 94
(2021/11/06)
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- Iron(III)-catalyzed aerobic oxidation and cleavage/formation of a C-S bond
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A new iron(III)-catalyzed synthesis of β-oxo sulfones is described that employs vinylarenes and readily available dimethyl sulfoxide (DMSO) with hydrazine and oxygen as the oxidant. The reaction tolerates various functional group substituents on the vinylarene substrates to afford β-oxo sulfones in moderate to good yields. The cleavage and formation of the C-S bond are the key steps of this transformation.
- Shi, Xiaokang,Ren, Xiaoyu,Ren, Zhiyong,Li, Jian,Wang, Yuling,Yang, Sizhuo,Gu, Jixiang,Gao, Qiang,Huang, Guosheng
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supporting information
p. 5083 - 5088
(2014/08/18)
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