- POTENTIAL ANTIDEPRESSANTS. SYNTHESIS OF 6,11-DIHYDRODIBENZOTHIEPIN-11-YL (DIMETHYLAMINOMETHYL)PHENYL ETHERS, SULFIDES, AMINES AND SOME RELATED COMPOUNDS
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Reactions of 11-chloro-6,11-dihydrodibenzothiepin and its 2-bromo derivative with the isomeric (dimethylaminomethyl)phenols, (dimethylaminomethyl)thiophenols, and (dimethylaminomethyl)anilines in toluene afforded the title compounds IIIb,c, Va, VIIIa,b,c, and Xa,b,c.Reactions of 11-chloro-6,11-dihydrodibenzothiepin and its 2-chloro and 2-methyl derivatives with N,N-dimethyl-2-(4-aminophenoxy)ethylamine and N,N-dimethyl-3-(4-aminophenoxy)propylamine by heating in dimethylformamide in the presence of sodium carbonate gave the diamino ethers XI-XIV.Thecompounds showed only indications of the antidepressant agents profile and some antimicrobial effects in vitro.
- Sindelar, Karel,Valenta, Vladimir,Holubek, Jiri,Matousova, Oluse,Protiva, Miroslav
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p. 282 - 295
(2007/10/02)
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