The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of us
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(2016/08/29)
Design considerations for PAMAM dendrimer therapeutics
We have previously shown that methotrexate (MTX) conjugated to a cancer-specific poly amido amine (PAMAM) dendrimer has a higher therapeutic index than MTX alone. Unfortunately, these therapeutics have been difficult to advance because of the complicated
Goonewardena, Sascha N.,Kratz, Jeremy D.,Zong, Hong,Desai, Ankur M.,Tang, Shengzhuang,Emery, Sarah,Baker Jr., James R.,Huang, Baohua
p. 2872 - 2875
(2013/06/27)
MULTIFUNCTIONAL SMALL MOLECULES
The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of us
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Page/Page column 55; 56
(2013/06/27)
The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry
The facile conjugation of three azido modified functionalities, namely a therapeutic drug (methotrexate), a targeting moiety (folic acid), and an imaging agent (fluorescein) with a G5 PAMAM dendrimer scaffold with cyclooctyne molecules at the surface thro
Huang, Baohua,Kukowska-Latallo, Jolanta F.,Tang, Shengzhuang,Zong, Hong,Johnson, Kali B.,Desai, Ankur,Gordon, Chris L.,Leroueil, Pascale R.,Baker Jr., James R.
p. 3152 - 3156
(2012/06/18)
Copper-free click conjugation of methotrexate to a PAMAM dendrimer platform
The synthesis of a generation 5 (G5) poly(amidoamine) (PAMAM) dendrimer platform having cyclooctyne ligands that were subsequently be used for a copper-free Huisgen 1,3-dipolar cycloaddition (click reaction) with azido modified methotrexate is described.
Huang, Baohua,Desai, Ankur,Zong, Hong,Tang, Shengzhuang,Leroueil, Pascale,Baker Jr., James R.
p. 1411 - 1414
(2011/06/10)
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