Convergent synthesis of dolastatin 15 by solid phase coupling of an N- methylamino acid
Convergent synthesis of dolastatin 15 (1), a cytostatic depsipeptide isolated from the Indian Ocean sea hare, has been described. For construction of the backbone, a single-step condensation of peptide fragment 2 and pyrrolidone fragment 3 was successfull
BroP: A new reagent for coupling N-methylated amino acids
BroP (bromo tris(dimethylamino) phosphonium hexafluorophosphate) is a particularly suitable reagent for coupling N-methylated amino acids. It is stable and gives very high yields in short reaction times. Dipeptides are obtained without appreciable epimeri
Coste,Dufour,Pantaloni,Castro
p. 669 - 672
(2007/10/02)
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