Controlling intracellular macrocyclization for the imaging of protease activity
(Figure Presented) Reporters on the ground: An intramolecular macrocyclization reaction took place highly efficiently in live cells under the control of a specific enzyme and reduction by glutathione (GSH; see picture). Macrocyclic products (represented as blue rings) synthesized in cells self-assembled into nanoparticles aggregated and retained at the site near the enzyme location to report local proteolytic activity in live cells.
Ye, Deju,Liang, Gaolin,Ma, Man Lung,Rao, Jianghong
p. 2275 - 2279
(2011/04/22)
More Articles about upstream products of 1289513-16-1