Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors
Quinazoline 3 was discovered as a novel c-jun N-terminal kinase (JNK) inhibitor with good brain penetration and pharmacokinetic (PK) properties. A number of analogs which were potent both in the biochemical and cellular assays were discovered. Quinazoline
He, Yuanjun,Kamenecka, Theodore M.,Shin, Youseung,Song, Xinyi,Jiang, Rong,Noel, Romain,Duckett, Derek,Chen, Weimin,Ling, Yuan Yuan,Cameron, Michael D.,Lin, Li,Khan, Susan,Koenig, Marcel,Lograsso, Philip V.
p. 1719 - 1723
(2011/05/05)
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