- Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles
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Having recently identified a so-far unexplored area adjacent to the known binding site of allosteric mitogen-activated protein kinase kinase (MEK) inhibitors, we now report an extension of these studies by combining our new side chains with different MEK
- Hartung, Ingo V.,Pühler, Florian,Neuhaus, Roland,Scholz, Arne,Siemeister, Gerhard,Geisler, Jens,Hillig, Roman C.,Von Ahsen, Oliver,Hitchcock, Marion
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p. 2004 - 2013
(2015/12/23)
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- SUBSTITUTED BENZOSULPHONAMIDES
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The present invention relates to substituted benzosulphonamide compounds of general formula (I) : in which R1, R2, R3, R4, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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Page/Page column 65-66
(2011/05/06)
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