- Direct synthesis of hydrogen peroxide from hydrogen and oxygen by using a water-soluble iridium complex and flavin mononucleotide
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H2, O2 to H2O2: The direct synthesis of hydrogen peroxide from hydrogen and oxygen in water has been made possible by using an iridium(III) complex, [IrIII(Cp)(4-(1H-pyrazol- 1-yl-κN2)benzoic acid-κC3)(H 2O)]2SO4, and flavin mononucleotide. This method gives hydrogen peroxide with a high turnover number (847) and yield (19.2 %) under normal pressure and at room temperature. Copyright
- Shibata, Satoshi,Suenobu, Tomoyoshi,Fukuzumi, Shunichi
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- Production technology for riboflavin sodium phosphate
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The invention relates to a production technology for riboflavin sodium phosphate. The invention aims to realize simple technology, easy control and high yield. The production technology comprises the following steps: performing phosphorylation reaction: adding phosphorus oxychloride and acetonitrile in turn, dropwise adding pyridine of which the weight is 2/3 of the total weight, slowly dropwise adding a solution prepared from the residual pyridine and purified water and reacting for 30-60 minutes; adding vitamin B2 for performing phosphorylation reaction for 20-40 minutes under the temperature at 30-37 DEG C; while crystallizing, adding riboflavin cyclophosphate seed crystal of which the weight is 0.25-0.5% of the weight of the vitamin B2 for promoting the crystallization; performing hydrolysis reaction: adding 18%-20% hydrochloric acid solution into the separated riboflavin cyclophosphate crystal and performing hydrolysis reaction for 1-3 hours under the temperature at 45-55 DEG C; adding sodium hydroxide for performing neutral reaction and separating, thereby acquiring a riboflavin sodium phosphate crude product; washing with methyl alcohol and ethanol solution and removing the impurities and organic residual matters from the riboflavin sodium phosphate; drying and crushing to the required particle size.
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Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0053
(2017/10/31)
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- Riboflavin sodium phosphate synthesis method and process (by machine translation)
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The invention relates to a method for producing medical products, in particular relates to a process for synthesis of riboflavin sodium phosphate, belongs to the technical field of pharmaceutical chemistry. The process mainly through ovoflavin and phosphorus oxychloride in a certain condition to produce riboflavin phosphate esterification reaction, filtering, removing the solid material, to hydrolyze the filtrate, to obtain crude sodium riboflavin phosphate, filter it, collecting filter cake, the filter cake to crystallization, the riboflavin sodium phosphate crystal, filtering, the filter cake by adding dryer are used for drying, to obtain the product. To the raw materials of this method, low cost, simple reaction, is easy to control, high yield, and can be used for mass production of the workshop. The Patent refers to the synthesis process of riboflavin sodium phosphate has broad application prospect. (by machine translation)
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Paragraph 0015; 0016; 0017; 0018; 0019; 0020; 0021; 0022
(2016/12/22)
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- Synthesis method and process of riboflavin sodium phosphate
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The invention relates to a method for producing pharmaceutical products, in particular to a synthesis process of riboflavin sodium phosphate, and belongs to the technical field of pharmaceutical chemistry. The synthesis process mainly comprises the following steps: carrying out an esterification reaction between riboflavin and phosphorus oxychloride under a certain conduction to generate riboflavin phosphate, filtering to remove solid matters, hydrolyzing the obtained filtrate to obtain a crude riboflavin sodium phosphate product, filtering the crude riboflavin sodium phosphate product, collecting filter cake, crystallizing the filter cake to obtain riboflavin sodium phosphate crystals, filtering, and adding the filtered filter cake into a dryer for drying, so that the product is obtained. The synthesis process has the advantages that the raw materials are easy to obtain; the cost is low; reactions are simple and easy to control; the yield is high; the synthesis process can be used for mass production in a workshop. The synthesis process has wide application prospect in the aspect of synthesis processes of riboflavin sodium phosphate.
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Paragraph 0015; 0016; 0017; 0018; 0019; 0020; 0021; 0022
(2017/01/17)
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- Synthetic method and technology of riboflavin sodium phosphate
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The invention relates to a method used for producing medical products, more specifically relates to a synthetic method of riboflavin sodium phosphate, and belongs to the technical field of pharmaceutical chemistry. In the synthetic method, esterification reaction of riboflavin and phosphorus oxychloride is carried out at certain conditions so as to obtain a riboflavin phosphate product; the riboflavin phosphate product is filtered, solid substances are removed, and an obtained filtrate is subjected to hydrolysis so as to obtain a riboflavin sodium phosphate crude product; the riboflavin sodium phosphate crude product is filtered, a filter cake is collected, and is subjected to crystallization so as to obtain a riboflavin sodium phosphate crystal product; and the riboflavin sodium phosphate crystal product is filtered, and an obtained filter residue is dried in a drier so as to obtain a finished product. The raw materials are easily available; cost is low; reaction is simple, and is convenient to control; yield is high; and the synthetic method can be applied to workshop large batch production. Application prospect of the synthetic method in the field of riboflavin sodium phosphate synthesis is promising.
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Paragraph 0016-0022
(2017/02/17)
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