cas 130-61-0, Thioridazine hydrochloride | Articles data ｜lookchem

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130-61-0

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THE (S)-ENANTIOMER OF MEPAZINE
The present invention relates to the (S)-enantiomer of mepazine, its applicability in therapy, a pharmacological composition comprising (S)-mepazine, and processes for the preparation of (S)- mepazine and one of its intermediates.
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(2015/01/16)

Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase
Second site: In the crystal structure of human MALT1casp-Ig3 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) in complex with the tricyclic phenothiazine derivative thioridazine (violet in the picture), the inhibitor is bound in a hydrophobic pocket far from the active site. This explains the action of phenothiazine derivatives as noncompetitive, reversible inhibitors. Copyright
Schlauderer, Florian,Lammens, Katja,Nagel, Daniel,Vincendeau, Michelle,Eitelhuber, Andrea C.,Verhelst, Steven H. L.,Kling, Dale,Chrusciel, Al,Ruland, Juergen,Krappmann, Daniel,Hopfner, Karl-Peter
supporting information
p. 10384 - 10387
(2013/10/21)

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50-52-2
thioridazine

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Chemical Properties

Appearance/Colour :Pale yellow solid
Melting Point: 158-160 °C
Boiling Point: 515.7 °C at 760 mmHg
Flash Point:265.7 °C
Density: 1.1227 (rough estimate)
Solubility:H2O: soluble250 mg plus 5 ml of solvent, clear, colorless to fai
Storage Temp.:Desiccate at RT
Vapor Pressure: 9.65E-11mmHg at 25°C
Refractive Index: 1.5610 (estimate)
Sensitive: Light Sensitive & Hygroscopic
Merck: 14,9359
PSA: 57.08000
LogP: 6.69050

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