- New trimethoxybenzamides and trimethoxyphenylureas derived from dimethylcarbazole as cytotoxic agents. Part i
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A convenient synthesis of novel functionalized 1,4-dimethylcarbazole derivatives containing 3,4,5-trimethoxybenzamido-ureido or N-(3,4,5- trimethoxyphenyl)ureido group starting from their corresponding indole derivatives is reported. Three derivatives pre
- Panno, Antonella,Sinicropi, Maria Stefania,Caruso, Anna,El-Kashef, Hussein,Lancelot, Jean-Charles,Aubert, Geneviève,Lesnard, Aurélien,Cresteil, Thierry,Rault, Sylvain
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p. E294-E302
(2014/11/08)
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- EFFICIENT SYNTHESIS OF 6-SUBSTITUTED 3-NITRO- AND -3-AMINO-1,4-DIMETHYLCARBAZOLES
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The acylation of 1,4-dimethylcarbazole, 1, by an acid chloride or acetic anhydride according to the Friedel-Crafts reaction led to diacylcarbazoles 4, 6, 8, 10, 11 or to monoacylcarbazoles 5, 7, 9, 12, 13 and 14.The 3-acetyl-6-methoxy-6-nitrocarbazoles co
- Lancelot, Jean-Charles,Letois, Bertrand,Rault, Sylvain,Dung, Nguyen Huy,Saturnino, Carmela,Robba, Max
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p. 301 - 307
(2007/10/02)
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- A SIMPLE ROUTE TO 3-AMINO-1,4-DIMETHYL-6-HYDROXY- (OR METHOXY-)CARBAZOLES
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A convenient synthesis of 3-amino-1,4-dimethyl-6-hydroxy- (or methoxy-)carbazoles was described starting from 1,4-dimethyl-6-hydroxycarbazole.Structures were confirmed by unequivocal synthesis.
- Lancelot, Jean-Charles,Letois, Bertrand,Rault, Sylvain,Robba, Max
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p. 241 - 246
(2007/10/02)
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- Etude de la cytotoxicite in vitro de derives du carbazole III. 3-Amino et 3-nitro-1,4-dimethyl-9H-carbazoles diversement substitutes en position 6
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The synthesis of a series of nitro and amino-1,4-dimethyl-9H-carbazoles is described.The cytotoxic activities, as assayed in vitro using clonogenic cell culture of murine leukemia L1210, vary greatly with the nature and position of substituents.The most cytotoxic derivatives, 3-amino-6-hydroxy 1,4-dimethyl-9H-carbazole, displays an activity similar to that of N2-methyl-9-hydroxy ellipticinium acetate (NMHE).These results, together with those previously published by us, allow a detailed analysis of structure-activity relationships in the 9H-carbazole and1,4-dimethyl-9H-carbazole series.For the 3-amino-1,4-dimethyl 9H-carbazole derivatives, a mechanism of action similar to that of ellipticine derivatives is proposed.
- Letois, B,Lancelot, J C,Rault, S,Robba, M,Tabka, T,et al.
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p. 775 - 784
(2007/10/02)
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