- Optically active compounds and intermediates thereof, and process for manufacturing same
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An optically active (S)- or (R)-pentane compound of the general formula (11): STR1 wherein R11, R12 and R13 independently represent a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms, R14 represents a hydroxy, protected hydroxy or oxo group, if R14 is an oxo group, the ring denoting benzene in the above formula (11) is benzoquinone, R15 represents a hydrogen atom, hydroxy or acyloxy group, R16 represents a hydroxy or acyloxy group, and the chiral central carbon marked with a symbol * in said formula (11) alternatively has one of an R-configuration and an S-configuration, is disclosed. Further, intermediate products of the compound of the formula (11) are also disclosed. Still further, a process for manufacturing the above compounds is disclosed. The compound of the formula (11) is easily synthesized from an easily available optically active starting material.
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- A CONVERGENT ENANTIOCONTROLLED ROUTE TO MEVALONOLACTONE AND VITAMIN E FROM (S)-O-BENZYLGLYCIDOL
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A convergent enantiocontrolled route to (+) and (-)-mevalonolactones and vitamin E has been developed using (S)-O-benzylglycidol as the sole chiral block.
- Takano, Seiichi,Shimazaki, Youichi,Iwabuchi, Yoshiharu,Ogasawara, Kunio
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p. 3619 - 3622
(2007/10/02)
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- Enantio-and Stereo-controlled Construction of Tertiary and Quaternary Carbon Centers Using Chiral O-Benzylglycidol as Template
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An efficient method for the enantio- and stereo-controlled construction of tertiary and quaternary carbon centers in a highly functionalized system has been developed using chiral O-benzylglycidol as template.
- Takano, Seiichi,Shimazaki, Youichi,Moriya, Minoru,Ogasawara, Kunio
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p. 1177 - 1180
(2007/10/02)
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- Enantiocontrolled synthesis of natural (+)-bakuchiol
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(+)-Bakuchiol (1), an irregular phenolic monoterpene of Psoralea corylifolia L., has been first synthesized in natural forms starting from (S)-O-benzylglycidol (2).
- Takano,Shimazaki,Ogasawara
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p. 3325 - 3326
(2007/10/02)
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