Synthesis and biological activity of some new 1-aryl-3-benzoxazinyldihydro-pyrimidinediones
Several new new 1-aryl-3-(3-oxo-2H-1, 4-benzoxazin-7-yl)-2, 3-dihydro-2-thioxo-4, 6(1H, 5H)pyrimidinediones (IV) have been synthesised by condensation of the corresponding 1, 3-disubstituted thioureas (III) with malonic acid and acetyl chloride. Only one compound (2) shows significant anti-inflammatory activity.
Ram,Singh,Chaturvedi,Sastry
p. 697 - 699
(2007/10/02)
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