- Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles
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Methods for preparing oxindole and thio-oxindole compounds are provided, which compounds are useful as precursors to useful pharmaceutical compounds. Specifically provided are methods for preparing 5-pyrrole-3,3-oxindole compounds and 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile. Also provided are methods for preparing iminobenzo[b]thiophene and benzo[b]thiophenone compounds.
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Page/Page column 17
(2008/06/13)
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- Solvation effects in the Grignard reaction with carbonyl compounds
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Ratios of the yields of addition and reduction products for the reactions of butylmagnesium chloride with diisopropyl ketone, methyl 2-methylpropanoate, and isopropyl 2-methylpropanoate in toluene were determined at different THF, diethyl ether, and tert-
- Sassian, Meeri,Tuulmets, Ants
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- Preparation of ketones via the palladium-catalyzed cross-coupling of acid chlorides with trialkylboranes
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Trialkylboranes react with acid chlorides in the presence of palladium to generate alkyl and aryl ketones in good yields. (C) 2000 Elsevier Science Ltd.
- Kabalka, George W.,Malladi, Rama R.,Tejedor, David,Kelley, Shane
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p. 999 - 1001
(2007/10/03)
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- Oxidation of Secondary Alcohols Using Raney Nickel
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A high yield, one-step oxidation procedure has been developed for the selective oxidation of secondary alcohols.
- Krafft, Marie E.,Zorc, Branka
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p. 5482 - 5484
(2007/10/02)
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- A VERSATILE ACCESS TO UNSYMMETRICAL AND SYMMETRICAL α-DIKETONES VIA ORGANOTIN REAGENTS
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Unsymmetrical α-diketones have been obtained via cross coupling of acyltins with acyl halides under PdCl2(PPh3)2 catalysis while symmetrical α-diketones have been readily obtained via "in situ" formation of acyltins using hexabutylditin and acyl chlorides under similar experimental conditions.
- Verlhac, Jean-Baptiste,Chanson, Evelyne,Jousseaume, Bernard,Quintard, Jean-Paul
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p. 6075 - 6078
(2007/10/02)
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- GRIGNARD REAGENT INDUCED SELF-CONDENSATION OF BENZOXAZOLES: SYNTHESIS OF BENZOXAZOLYLALKYL ALKYL KETONES.
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2-Alkylbenzoxazoles 1 undergo clean Claisen-type self-condensation upon treatment with n-BuMgBr and quenching with aqueous NH4Cl to give 5.In contrast, quenching of the reaction with aqueous HCl furnishes quite good yields of the benzoxazolylalkyl alkyl ketones 8.
- Florio, Saverio,Ingrosso, Giovanni,Sgarra, Riccardo
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p. 3091 - 3094
(2007/10/02)
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- METAL-HALOGEN EXCHANGE-INITIATED CYCLIZATION OF IODO CARBONYL COMPOUNDS
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The feasability of constructing carbocycles through the metal-halogen exchange-initiated cyclization reactions of iodoketones and other carboxyl derivatives has been studied.With saturated primary iodides, cyclization predominates when deactivated ketones are employed.
- Cooke, Manning P.,Houpis, Ioannis N.
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p. 4987 - 4990
(2007/10/02)
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- GENERAL RELATIONSHIPS IN THE OPENING OF THE OXIRANE RING DURING CLEAVAGE OF GLYCIDIC ACIDS
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By investigation of the decarboxylation of 2,3-epoxy derivatives of acids with various structures it was shown that contrary to the existing theory about the essential opening of the β (C-O) bond in the oxirane ring there are many structural types of 2,3-epoxypropionic acids, in which opening of the α (C-O) bond in the oxirane ring occurs during decarboxylation.It was also shown that these two possible reaction paths can also arise during the decarboxylation of one 2,3-epoxypropionic acid.On the basis of the obtained data a general relationship is developed for theopening of the oxirane ring during the decarboxylation of 2,3-epoxypropionic acids with any structure, and this makes it possible to predict the structure of the obtained carbonyl compound.
- Kuroyan, R. A.,Markosyan, A. I.,Engoyan, A. P.,Vartanyan, S. A.
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p. 1709 - 1714
(2007/10/02)
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- Reaction of Lithium Dialkylcuprates with S-2-Pyridiyl Thioates in the Presence of Oxygen. A Carboxylic Ester Synthesis
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Reaction of lithium dialkylcuprates with S-2-pyridyl thioates in the presence of oxygen affords carboxylic esters in high yields, whereas under nitrogen it affords ketones.
- Kim, Sunggak,Lee, Jae In,Chung, Bong Young
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p. 1231 - 1232
(2007/10/02)
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