Antipicornavirus Activity of Tetrazole Analogues Related to Disoxaril
A series of tetrazole analogues of Win 54954, a broad-spectrum antipicornavirus compound, has been synthesized to address the acid lability of the oxazoline ring of this series of compounds.The results of X-ray crystallography studies of several members o
Diana, Guy D.,Cutcliffe, David,Volkots, Deborah L.,Mallamo, John P.,Bailey, Thomas R.,et al.
CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14
A CoMFA analysis of eight compounds related to disoxaril whose X-ray structures bound to HRV-14 had been determined resulted in a strong positive correlation of activity with steric effects of the compounds, particularly toward the pore end of the compoun
Diana,Kowalczyk,Treasurywala,Oglesby,Pevear,Dutko
p. 1002 - 1008
(2007/10/02)
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