- 3-(AMINOARYL)-PYRIDINE COMPOUNDS
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The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are pharmaceutical compositions containing these compounds and methods of treating a disease or condition mediated by CDK9 using these compounds and compositions.
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Page/Page column 108
(2012/06/01)
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- Selective catalytic hydrogenation of nitro groups in the presence of activated heteroaryl halides
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Chemoselective reduction of nitro groups in the presence of activated heteroaryl halides was achieved via catalytic hydrogenation with a commercially available sulfided platinum catalyst. The optimized conditions employ low temperature, pressure, and catalyst loading (0.1 mol % Pt) to afford heteroaromatic amines with minimal hydrodehalogenation byproducts.
- Kasparian, Annie J.,Savarin, Cecile,Allgeier, Alan M.,Walker, Shawn D.
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experimental part
p. 9841 - 9844
(2012/01/06)
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