- Solid-phase synthesis of substituted pyrazolones from polymer-bound β-keto esters
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Polymer-bound acetoacetate 3 was γ-mono- and γ-dialkylated, as well as α-monoalkylated, to give 6, 9, and 13, respectively. Treatment with hydrazine or substituted hydrazines followed by thermal or acidic cyclizing cleavage yielded the pyrazolones 17a-dd in a purity of >90%.
- Tietze, Lutz F.,Evers, Holger,Hippe, Thomas,Steinmetz, Adrian,T?pken, Enno
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p. 1631 - 1634
(2007/10/03)
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