STUDIES ON INTRAMOLECULAR MANNICH REACTION OF (S)-2-(&α-HYDROXYETHYL)BENZIMIDAZOLE. SYNTHESIS OF (1S)-4-ARYL-4,5-DIHYDRO-1-METHYL-1H,3H-OXADIAZEPINOBENZIMIDAZOLES - A NEW CLASS OF HETEROCYCLIC COMPOUNDS
The intramolecular Mannich reaction of (S)-2-(α-hydroxyethyl)benzimidazole with primary aromatic amines IIa-g and formaldehyde has been shown to furnish a new class of heterocyclic compounds: (1S)-4-aryl-4,5-dihydro-1-methyl-1H,3H-oxadiazepinobenzimidazoles IIIa-g.The antibacterial activity of these compounds has also been evaluated.
Hussain, Shaheen A.,Sarfaraz, Tahira B.,Sultana, Naheed,Murtaza, Najma,Qureshi, Izbar H.
p. 1245 - 1250
(2007/10/02)
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