- A method for preparing high-purity hydrochloric acid Nepal non-Kalland
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The invention discloses a preparation method of nifekalant hydrochloride. The preparation method comprises the following steps of: performing aminolysis on 6-imino-1,3-dimethyluracil to obtain 1,3-dimethyl-6-(2-ethoxy)aminouracil; esterfying 1,3-dimethyl-
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- Pyrimidinedione derivatives and antiarrhythmic agents containing same
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Pyrimidinedione derivatives of the formula: STR1 wherein R1 and R2 is so linked with each other as to make an alkylene chain and thus form a heterocyclic structure, A, R3, R4, X1, X2 and X3 are substituents, respectively, and n is 2 or 3 have a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain and a heterocyclic ring having two nitrogen atoms. These compounds are useful for a medical treatment of cardiac arrhythmias.
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- Synthesis and pharmacological studies of N-substituted 6-[(2- aminoethyl)amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinediones, novel class III antiarrhythmic agents
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A series of 6-[(2-aminoethyl)amino]-1,3-dimethyl-2,4(1H,3H)- pyrimidinedione derivatives were synthesized and studied for their class III electrophysiological activity and class II (β-blocking) effects in in vitro and in vivo models. Structure-activity re
- Katakami,Yokoyama,Miyamoto,Mori,Kawauchi,Nobori,San-nohe,Kaiho,Kamiya
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p. 3325 - 3330
(2007/10/02)
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- Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same
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A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain containing at least two nitrogen atoms. The pyrimidinedione derivative is useful for a medical treatment of cardiac arrhythmias.
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