- Neticonazole hydrochloride preparation method
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The invention discloses a neticonazole hydrochloride preparation method, which comprises: carrying out an acylation reaction on imidazole and o-hydroxybenzoic acid, carrying out a wittig reaction on the product of the acylation reaction and 1-halogenated dimethyl sulfide, carrying out a reaction on the product of the wittig reaction and 1-halogenated pentane in an inorganic alkali, and salifying the product of the reaction and hydrochloric acid to obtain the neticonazole hydrochloride. According to the present invention, the method can avoid the use of the methanethiol and thionyl chloride, has characteristics of environmental protection, mild reaction condition, simple operation, simple post-treatment and high product purity, and is suitable for industrial production.
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