- Palladium-Catalyzed Direct C-H Arylation of Isoxazoles at the 5-Position
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A palladium-catalyzed direct arylation of isoxazoles with aryl iodides has been achieved. The C-H bond at the 5-position is activated selectively to give coupling products in moderate to good yields. This direct arylation was applied to the synthesis of a spiro-type chiral ligand, which proved to be most effective to the palladium-catalyzed tandem cyclization of a dialkenyl alcohol.
- Shigenobu, Masashi,Takenaka, Kazuhiro,Sasai, Hiroaki
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supporting information
p. 9572 - 9576
(2015/08/11)
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- Ruthenium-catalyzed cycloaddition of nitrile oxides and alkynes: Practical synthesis of isoxazoles
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(Chemical Equation Presented) 3,4-Disubstituted and 3,4,5-trisubstituted isoxazoles have been formed from alkynes and nitrile oxides in a ruthenium(II)-catalyzed process (see scheme; cod=cycloocta-l,5-diene, Cp=C5Me5). These reaction
- Grecian, Scott,Fokin, Valery V.
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supporting information; experimental part
p. 8285 - 8287
(2009/04/13)
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- Processes for the preparation of substituted isoxazoles and 2-isoxazolines
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Provided are compounds, processes and synthetic intermediates useful for the preparation of compounds of the formula I and IX wherein R1 is selected from the group consisting of hydrogen, trihalomethyl, C1-C6 alkyl and substituted or unsubstituted phenyl; Y is a group of the formula wherein R2 is selected from the group consisting of C1-C6 alkyl, C1-C6 alkanoylamino and amino; and R5 is selected from the group consisting of hydrogen, amino, halogen, hydroxyl, nitro, C1-C6 alkyl, C1-C6 alkoxy, carboxy, C1-C6 trihaloalkyl, cyano, phosphonato, and hydroxyalkyl; and Z is selected from the group consisting of substituted and unsubstituted aryl. Also provided are certain N-acylated analogs of compounds of the formula I and IX, and processes for their preparation.
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- SYNTHESIS AND PROPERTIES OF AZOLES AND THEIR DERIVATIVES. PART XX. STUDIES ON THE THERMOLYSIS OF REGIO AND STEREOISOMERIC DIARYLNITRO-Δ2-ISOXAZOLINES
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Thermolysis of stereoisomeric 3,5-diaryl-4-nitro-Δ2-isoxazolines 1, 3, depending on the applied solvent, leads to 3,5-diarylisoxazoles 4 or mixtures of 3,5-diarylisoxazoles 4 and 3,5-diaryl-4-nitroisoxazoles 6.Under similar conditions, 3,4-diar
- Baranski, Andrzej,Cholewka, Elzbieta
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p. 483 - 494
(2007/10/02)
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