Enantioselective synthesis of tertiary alcohols through a zirconium-catalyzed Friedel-Crafts alkylation of pyrroles with α-ketoesters
Chiral complexes of 1,1′-bi-2-naphthol-based ligands with zirconium tert-butoxide catalyze the Friedel-Crafts alkylation of pyrroles with α-ketoesters to afford tertiary alcohols in good yields and ee up to 98%. The reaction is also of application to 4,7-dihydroindole to give C2-alkylated indoles after oxidation with p-benzoquinone.
Blay, Gonzalo,Fernandez, Isabel,Munoz, M. Carmen,Pedro, Jose R.,Recuenco, Alejandro,Vila, Carlos
experimental part
p. 6286 - 6294
(2011/10/01)
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