- Total synthesis of the proposed structure of briarellin J
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The total synthesis of the originally proposed structure of briarellin J is reported in 15 steps from a known compound and in 23 steps from readily available materials. Key reactions include an exo-selective intramolecular Diels-Alder and a substrate-cont
- Crimmins, Michael T.,Mans, Mark C.,Rodriguez, Abimael D.
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Read Online
- NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPAR-RECEPTORS
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Novel biaromatic compounds that modulate peroxisome proliferator-activator receptors, known as PPAR, having the formula (I): are formulated into pharmaceutical compositions useful in human or veterinary medicine, or alternatively, in cosmetic compositions.
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Page/Page column 18; 25
(2009/01/23)
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- Benzannelated derivatives, their manufacture and use as pharmaceutical agents
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There are presented compounds of the formula wherein R6 and R7 is R4 and R5 or R5 and R6 together with the carbon atoms to which they are attached, form a ring as defined in the description
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Page/Page column 24
(2008/06/13)
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- Total synthesis of bafilomycin A1. 2. The assemblage and completion of the synthesis
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The total synthesis of the macrolide antibiotic, bafilomycin A1 (1), has been achieved by a convergent route involving aldol condensation between the 16-membered lactonic aldehyde 2 and the ethyl ketone 3, followed by desilylation.
- Toshima, Kazunobu,Yamaguchi, Hiroyuki,Jyojima, Takaaki,Noguchi, Yasunobu,Nakata, Masaya,Matsumura, Shuichi
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p. 1073 - 1076
(2007/10/03)
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- Cephem derivatives
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What are disclosed are cephem compounds of the formula STR1 in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group --CH2 Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2 O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.
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