Interception of amide ylides with sulfonamides: Synthesis of (: E)- N -sulfonyl amidines catalyzed by Zn(OTf)2
Through the interception of amide ylides with sulfonamides, we herein report the first general example of an intermolecular condensation reaction between sulfonamides and amides. Beyond formamides, this approach was successfully applied to a variety of lactams and linear amides, giving rise to a broad array of (E)-N-sulfonyl amidines.
Reactions and Diastereoselectivity of N2-Arylsulfonyl Amidine Anions
Cyclic N1-alkyl-N2-sulfonyl amidine anions undergo stereoselective aldol reactions to give the syn diastereoisomer as the major product.The ratio of syn to anti aldol products decreases as the size of the N1-alkyl increase
Magnus, Philip,Moursounidis, John
p. 1529 - 1534
(2007/10/02)
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